Custom Peptides
Cayman Chemical N-Desbutyl Drondaronhydro 10mg
An active metabolite of dronedarone; inhibits T3 binding to TRα1 and TRβ1 (IC50s = 59 and 280 µM for the chicken and human receptors, respectively); inhibits CYP2J2-mediated formation of 14,15-EET from arachidonic acid and soluble epoxide hydrolase-mediated formation of 14,15-DHET from 14,15-EET (IC50s = 1.59 and 2.73 µM, respectively, in cell-free assays); decreases intracellular ATP levels in H9c2 rat cardiomyocytes (IC50 = 1.07 µM); inhibits mitochondrial complex I and mitochondrial complex II activities in isolated rat heart mitochondria (IC50s = 11.94 and 24.54 µM, respectively)
Cayman Chemical 5-AEDBhydrochlorIde 10mg
An analytical reference standard categorized as a benzofuran; has been found in samples seized by law enforcement; intended for research and forensic applications
Cayman Chemical ScutelarIa WogonsIde 10mg
A flavonoid with anti-inflammatory and anticancer activities; an active metabolite of wogonin; decreases colonic pathological damage and myeloperoxidase and iNOS activity, as well as inhibits NF-κB and NLRP3 inflammasome activation in a DSS-induced mouse model of colitis at 25 and 50 mg/kg; inhibits phosphorylation of mTOR, as well as inhibits the growth of (IC50 = 133.9 µM), and induces autophagy in, MDA-MB-231 breast cancer cells; inhibits tube formation by HUVECs, increases Wnt3a levels and β-catenin phosphorylation in MCF-7 cells at 50-100 µM; reduces tumor growth and angiogenesis in an MCF-7 mouse xenograft model at 80 mg/kg
Cayman Chemical DapIglutIdesodIum salt 10mg
A dual GLP-1R and GLP-2R agonist; induces cAMP accumulation in HEK293 cells expressing human GLP-1R or GLP-2R (EC50s = 190 and 210 pM, respectively); reduces peak blood glucose levels in an oral glucose tolerance test and increases intestinal wet weight in mice at 6 nmol/kg; decreases gastric emptying and increases intestinal weight and length in rats (ED50s = 7.6, 20.7, and 10.7 nmol/kg, respectively); promotes body weight recovery, decreases stool water content, and increases intestinal villus height and intestinal length in a mouse model of short bowel and intestinal insufficiency induced by 40% ileocecal resection
Cayman Chemical OrphenadrInhydrochlorIde 10mg
A muscarinic acetylcholine receptor antagonist (Kds = 48, 213, 120, 170, and 129 nM for M1-M5 mAChRs, respectively); decreases oxotremorine-induced muscle activity in rabbits at 2-5 mg/kg; an NMDA receptor antagonist (Ki = 6 µM in human postmortem frontal cortex; IC50 = 16.2 µM in cultured superior colliculus neurons)
Cayman Chemical Prenylamn 10mg
A calcium channel inhibitor; inhibits PMCA in isolated and purified pig cardiac sarcolemma; binds to a hydrophobic site on calcium-bound calmodulin (CaM) with a Kd value of 0.5 µM and inhibits CaM-activated cAMP PDE activity at 10-50 µM, an effect that is negatively associated with the concentration of calmodulin; shortens action potentials and decreases the inward calcium current in single guinea pig ventricular myocytes in the absence and presence of propranolol and phentolamine at 30 μM; decreases epinephrine, serotonin, and dopamine levels in rat brain at 50 mg/kg; decreases epinephrine levels in rat heart; protects anesthetized rats from coronary artery occlusion-induced arrhythmia at 0.5 mg/kg but increases mortality due to atrioventricular block leading to asystole at 5 mg/kg
Cayman Chemical DeterenolhydrochlorIde 10mg
A β-adrenergic receptor agonist; increases tension in isolated right and left guinea pig atria and trachea (IC50s = 0.411, 1.44, and 8.37 µM, respectively), which endogenously express β-ARs, but has no effect on isolated rabbit aortic strips, which express α-ARs; induces lipolysis in human adipocytes
Cayman Chemical -FunaltrexamInhydrochlorI 10mg
A μ- and κ1-opioid receptor antagonist (Kis = 0.3 and 0.2 nM, respectively); selective for μ- and κ1-opioid receptors over the δ-opioid receptor (Ki = 12.8 nM); reversibly inhibits electricity-induced twitches of isolated guinea pig ileal longitudinal muscle strips (IC50 = 48 nM), indicating opioid agonist activity; inhibits endomorphin 1-induced conditioned place preference in mice at 0.3 UG/animal, i.c.v.; prevents decreases in urine output induced by fentanyl, D-propoxyphene, buprenorphine, profadol, or bromadoline in water-loaded rats at 40 mg/kg; reduces hemokinin 1-induced increases in the latency to withdrawal in the tail-flick test in mice
Cayman Chemical HeptamInolhydrochlorIde 10mg
An analytical reference standard categorized as a cardiac stimulant; has been found in PED samples seized by law enforcement; intended for research and forensic applications
Cayman Chemical OrforglIpron 10mg
A nonpeptide GLP-1R agonist; induces cAMP accumulation in HEK293 cells expressing human GLP-1R (EC50 = 3.05 nM); selective for GLP-1R over the GCGR, GIP receptor, and GLP-2R at 100 nM; ) prevents increases in blood glucose levels in glucose-injected mice expressing human GLP-1R but not in glucose-injected Glp1r-/- mice at 0.1, 1, or 10 mg/kg; decreases blood glucose and serum insulin levels in glucose-injected cynomolgus monkeys at 5.4 mg/kg; reduces mean food intake in cynomolgus monkeys at 0.05 or 0.1 mg/kg per day
Cayman Chemical SImvastatIn-d6 10mg
An internal standard for the quantification of simvastatin by GC- or LC-MS
Cayman Chemical ODesmethyl VenlafaxInd 10mg
An internal standard for the quantification of (±)-O-desmethyl venlafaxine by GC- or LC-MS; intended for research and forensic applications
Cayman Chemical 13C64NItrophenylhydrazIn 10mg
An internal standard for the quantification of 4-nitrophenylhydrazine by GC- or LC-MS; a byproduct in the synthesis of 13C6-3-nitrophenylhydrazine
Cayman Chemical Atrazn-d5 10mg
An internal standard for the quantification of atrazine by GC- or LC-MS
Cayman Chemical MItoquInonmesylate 10mg
An oxidized form of mitoquinol; reduced to mitoquinol in isolated bovine heart mitochondrial membranes using succinate for respiration at 50 µM; increases the rate of hydrogen peroxide formation in isolated BAECs at 0.01-10 µM; induces cell death in isolated mouse pancreatic acinar cells at 1 µM; in combination with mitoquinol, reduces MDA levels in isolated rat liver mitochondria and decreases caspase activity in Jurkat cells